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Senolytic Complex

Clear senescent cells

$35

per box

Protocol

Description

Target one of the major hallmarks of aging with a breakthrough product that clears senescent cells. When cells age or experience excessive stress, they enter a "zombie-like" state called senescence. Senescent cells secrete pro-inflammatory molecules that can trigger neighboring healthy cells to age faster—like a moldy piece of fruit. As we age, our ability to clear senescent cells declines, and preclinical studies suggest that their accumulation contributes to accelerated aging. Elysium’s Senolytic Complex is based on leading institutional research in the field of cellular senescence and contains senolytic compounds proven to clear human senescent cells to:

  • Help your body manage senescent cells
  • Promote cellular rejuvenation
  • Manage age-related inflammation
  • Improve exercise recovery, endurance, and muscle remodeling
  • Support a healthy immune system
  • Optimize cellular youth when combined with NAD+ boosters

Ingredients

Designed to be taken intermittently to help the body manage senescent cell burden.

  • Senolytics for targeting senescent cells: quercetin (Sophora japonica), fisetin (Rhus succedanea), extracts of Chinese ginseng (Panax notoginseng), and chestnut rose (Rosa roxburghii). 
  • Gluten-free, nut-free, and contains no artificial colors or flavors. 
  • NSF Certified for Sport, the only independent third-party certification program recognized by the United States Anti-Doping Agency (USADA). Please confirm the certification of each lot here.
  • See nutrition label for more information.
  • The quality and purity information of every lot is available here.

Recommended Use

Whether your goal is healthy aging, managing age-related inflammation, or supporting an active lifestyle, Elysium’s Senolytic Complex enables you to easily personalize your senolytic protocol. 

  • Healthy aging: For healthy aging and general wellness, we recommend 2 doses per month: 4 capsules per day for 2 consecutive days at the beginning of each month.
  • Inflammaging: To target senescent cell buildup and inflammation related to aging, we recommend doubling the healthy aging protocol by taking a second 2-day dose mid-month.
  • High performance + athlete support: High-performance individuals may benefit from a more frequent dosing schedule (e.g., a 2-day dose every week). Best if taken the day before and the day of your most strenuous exercise.
  • The healthy aging protocol includes 2 daily doses (2 sachets or 8 capsules) per month (delivered in a dark green box). 
  • The inflammaging protocol includes 4 daily doses (4 sachets or 16 capsules) per month (delivered in a mint green box).
  • The high performance protocol includes 8 daily doses (8 sachets or 32 capsules) per month (delivered in two mint green boxes).
  • This product is intended for healthy adults. If pregnant or nursing, consult with your physician before using. 
View full details

What is cellular senescence?

Everyone has senescent cells, and they are present throughout our body, including in the skin, brain, muscles, and heart. Everyday stressors, including poor diet, lack of sleep, psychological stress, and sun and environmental exposure, can trigger cells to become senescent. Normally, senescent cells are cleared within days to weeks by our immune cells. As we age, however, senescent cells accumulate—accumulating exponentially faster after 60—and impede immune function, creating a snowball effect that leads to even more senescent cells. As they build up in our body and persist, senescent cells can induce “inflammaging”, a type of inflammation associated with aging, and alter the microenvironment of the tissue and its function. 

Proven to clear senescent human cells

Elysium’s Senolytic Complex is based on leading institutional research in the field of cellular senescence and has been demonstrated to clear senescent cells in two different human cell lines in laboratory studies. The formulation contains fisetin and quercetin, two extensively researched flavonoids found in fruits and vegetables with potent senolytic activity. The Complex also includes powerful compounds derived from Chinese ginseng and chestnut rose extracts, which have been shown in human clinical trials to accelerate senescent cell clearance, improve recovery and endurance, and support muscle remodeling and cellular rejuvenation after strenuous exercise. 

senolytic graph
Leonard Guarente, Ph.D., chief scientist and co-founder of Elysium Health

“Cellular senescence is one of the most important hallmarks of aging and it has been implicated in a wide range of age-related conditions. Senolytic compounds, which specifically clear senescent cells, have shown great promise for health benefits preclinically, leading to many ongoing human trials.”

Leonard Guarente, Ph.D.,Elysium Co-founder and Chief Scientist

Personalized senolytic protocols to meet your goals

Whether your goal is healthy aging, managing inflammaging, or supporting an active lifestyle, Elysium’s Senolytic Complex enables you to easily personalize your senolytic protocol: a once monthly “hit-and-run” approach where two doses are taken on consecutive days to support healthy aging and general wellness; a twice-monthly approach to target greater senescent cell buildup and inflammaging; and a more frequent dosing schedule for athletes and individuals regularly engaging in intense exercise or high-stress occupations.

Level up your longevity protocol

When you combine Basis or Signal to boost NAD+ with the Senolytic Complex to clear senescent cells, you’re delivering a one-two punch to promote cellular youth and decrease the burden of pro-inflammatory cells.

Senolytic Complex: The Science

What is cellular senescence?

Cellular senescence is a phenomenon in which cells cease to divide but remain metabolically active. Learn about the causes and consequenc...

What are senolytics?

Senolytics target aging at the cellular level by helping the body clear senescent cells that accumulate with age.

The connection between senescence and inflammaging

Cell senescence is one of the major causes of inflammaging. Learn more about the causes of age-related inflammation and how we can manage...

Frequently Asked Questions

What is the Senolytic Complex?

The formulation of Elysium’s Senolytic Complex is based on leading research in the field of cellular senescence and is proven to clear senescent human cells in laboratory studies. The Complex contains potent senolytics quercetin (Sophora japonica) and fisetin (Rhus succedanea). It also contains extracts of Chinese ginseng (Panax notoginseng) and chestnut rose (Rosa roxburghii), which further support normal senolytic activity, and promote exercise recovery and endurance after strenuous exercise.

What is cellular senescence?

When cells age or experience excessive stress, they enter a zombie-like state called senescence. Senescent cells secrete pro-inflammatory molecules that can trigger neighboring healthy cells to age faster. As we age, our ability to clear these cells declines and they accumulate over time. Adding Elysium’s Senolytic Complex to your health routine can aid in removing senescent cell buildup.

Can I take the senolytic with your other supplements?

Yes! You’re welcome to take the Senolytic Complex alongside our other Elysium supplements and no contraindications or interactions have been observed. In addition, combining senolytics compounds that clear senescent cells with NAD+ boosting supplements like Basis or Signal may support a more comprehensive method to improve your healthy-to-senescent cell ratio.

Why should I take a senolytic with Basis or Signal?

The age-related decline in NAD+ levels compromises cellular health and can promote cellular senescence. Senescent cells, which are metabolically demanding and consume large amounts of NAD+, can further exacerbate the decline of this vital coenzyme. Combining senolytics, which clear senescent cells, with NAD+ boosters like Basis or Signal, which promote cellular health, delivers a one-two punch to promote cellular youth and decrease the burden of pro-inflammatory cells.

Is this the same complex that’s in Format?

Yes, this is the same Senolytic Complex that’s part of the Format two-part system. Based on customer feedback, we are providing the option to purchase the Senolytic Complex separately to enable our customers to tailor their senolytic routine.

Can I add a different protocol to my active Format subscription?

Format’s two-part system includes 1 box of Elysium’s Senolytic Complex, equivalent to the Healthy Aging protocol. Format as a product will not change and will continue to be offered as a two-part innovative system designed to provide advanced immune support. If you are looking to adjust the dosage of the Senolytic Complex, you’re welcome to place a separate subscription order in addition to your current Format deliveries to achieve the desired protocol.